Vitamin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Vitamin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDM2, SLC44A3, and PHLDA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MDM2 grouped by Vitamin biosynthetic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MDM2 →	-1.390	-1.062	<.001	<.001	3	4
OVARY	SLC44A3 →	-1.486	-0.976	.001	<.001	3	4
OVARY	PHLDA3 →	-2.456	-1.211	.007	<.001	3	4
KIDNEY	HIVEP3 →	-1.154	-1.423	.002	.002	2	5
KIDNEY	ZBTB7C →	-1.307	-1.506	.002	.001	3	4
SKIN	MME →	+2.455	+0.903	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MDM2 by Vitamin biosynthetic process activity — OVARY

Explore this box plot interactively →