Vitamin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Vitamin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSAT1, LONP1, and TMEM14B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin biosynthetic process activity versus PSAT1 in BLOOD_Leukemia (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PSAT1 →	+2.158	+0.930	<.001	<.001	3	8
OVARY	LONP1 →	+0.866	+1.128	.001	<.001	3	7
LUNG_SCLC	TMEM14B →	-0.593	-0.982	.003	.002	3	5
BLOOD_Leukemia	SHMT2 →	+0.623	+0.858	.009	.001	3	5
CNS	SPG21 →	-0.394	-1.043	.003	.001	3	4
OESOPHAGUS	DLX2 →	-0.668	-1.313	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009110 vs PSAT1 — BLOOD_Leukemia

Explore this scatter interactively →