Branched-chain amino acid catabolic process

Across TCGA patient cohorts, RNA activity of the Branched-chain amino acid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COLGALT1, AHCYL1, and FLNB_S983, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branched-chain amino acid catabolic process activity versus COLGALT1 in GBM (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COLGALT1 →	-0.533	-0.041	<.001	.003	3	7
GBM	AHCYL1 →	+0.454	+0.071	<.001	<.001	3	7
LUAD	FLNB_S983 →	-0.685	-0.046	<.001	.001	3	7
BRCA	ALDH6A1 →	+0.473	+0.054	<.001	<.001	3	7
LSCC	JUNB →	-0.529	-0.057	<.001	<.001	3	7
LUAD	MAP4_S696 →	-0.820	-0.055	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009083 vs COLGALT1 — GBM

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