Branched-chain amino acid catabolic process

Across TCGA cell cohorts, RNA activity of the Branched-chain amino acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCTN1, PINK1, and CDKL5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCTN1 grouped by Branched-chain amino acid catabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TCTN1 →	-1.062	-1.204	<.001	<.001	3	5
BREAST	PINK1 →	-1.087	-1.056	<.001	<.001	3	4
CNS	CDKL5 →	-0.663	-0.887	.001	.002	3	4
LIVER	ATP6AP2 →	-1.179	-1.197	.005	.006	3	4
LUNG_NSCLC_LUSC	HMGCL →	-0.793	-1.362	.001	<.001	3	4
LUNG_NSCLC_LUSC	CALU →	-1.356	-1.479	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCTN1 by Branched-chain amino acid catabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →