Branched-chain amino acid catabolic process

Across TCGA cell cohorts, RNA activity of the Branched-chain amino acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAAH, SCX, and ERBB3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branched-chain amino acid catabolic process activity versus FAAH in OVARY (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FAAH →	+2.416	+0.405	<.001	.006	3	9
URINARY_TRACT	SCX →	+1.217	+0.432	<.001	.001	3	8
PANCREAS	ERBB3 →	+2.858	+0.482	<.001	<.001	3	8
PANCREAS	ANO9 →	+2.702	+0.498	<.001	<.001	3	8
PANCREAS	TMEM45B →	+3.419	+0.389	<.001	<.001	3	7
OVARY	SACS →	-1.411	-0.369	.004	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009083 vs FAAH — OVARY

Explore this scatter interactively →