Branched-chain amino acid metabolic process

Across TCGA patient cohorts, RNA activity of the Branched-chain amino acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FUCA1, AKAP8, and GAS2L3_S431, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branched-chain amino acid metabolic process activity versus FUCA1 in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FUCA1 →	+0.664	+0.065	<.001	<.001	3	7
LSCC	AKAP8 →	-0.292	-0.048	.003	.004	3	6
BRCA	GAS2L3_S431 →	-1.442	-0.073	<.001	<.001	3	6
OV	PA2G4 →	-0.232	-0.023	.001	.006	3	6
BRCA	RNASEL →	+0.393	+0.053	<.001	<.001	3	6
LSCC	SELENBP1 →	+0.482	+0.057	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009081 vs FUCA1 — BRCA

Explore this scatter interactively →