Branched-chain amino acid metabolic process

Across TCGA patient cohorts, RNA activity of the Branched-chain amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUF2, ZWILCH, and UBE2T, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branched-chain amino acid metabolic process activity versus NUF2 in BRCA (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NUF2 →	-1.069	-0.120	<.001	<.001	3	7
LSCC	ZWILCH →	-0.762	-0.155	<.001	<.001	3	7
COAD	UBE2T →	-0.875	-0.231	<.001	<.001	3	7
COAD	CDC6 →	-0.857	-0.229	<.001	<.001	3	7
GBM	CDCA8 →	-0.832	-0.095	<.001	<.001	3	7
GBM	CENPI →	-0.663	-0.117	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009081 vs NUF2 — BRCA

Explore this scatter interactively →