Branched-chain amino acid metabolic process

Across TCGA cell cohorts, RNA activity of the Branched-chain amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYEOV, FPGT, and MAGED1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYEOV grouped by Branched-chain amino acid metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MYEOV →	+2.150	+0.956	.005	<.001	3	4
OVARY	FPGT →	-0.737	-0.971	<.001	.002	3	4
LUNG_NSCLC_LUSC	MAGED1 →	-2.523	-1.374	.001	.005	3	4
LUNG_NSCLC_LUSC	TCTN1 →	-1.064	-1.122	<.001	<.001	3	4
BLOOD_Leukemia	H6PD →	-1.480	-0.899	<.001	<.001	3	4
OVARY	YIPF2 →	-0.933	-1.172	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYEOV by Branched-chain amino acid metabolic process activity — OVARY

Explore this box plot interactively →