Branched-chain amino acid metabolic process

Across TCGA cell cohorts, RNA activity of the Branched-chain amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM45B, FAAH2, and ERBB3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branched-chain amino acid metabolic process activity versus TMEM45B in PANCREAS (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TMEM45B →	+3.488	+0.402	<.001	<.001	3	8
PANCREAS	FAAH2 →	+2.167	+0.442	<.001	<.001	3	8
PANCREAS	ERBB3 →	+2.852	+0.492	<.001	<.001	3	8
URINARY_TRACT	FAAH →	+2.579	+0.539	.008	.001	3	8
URINARY_TRACT	ABL2 →	-1.960	-0.560	<.001	.002	3	8
OVARY	SACS →	-1.669	-0.385	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009081 vs TMEM45B — PANCREAS

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