Aromatic amino acid metabolic process

Across TCGA patient cohorts, RNA activity of the Aromatic amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPX2, ZNF286B, and MEX3A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aromatic amino acid metabolic process activity versus TPX2 in BRCA (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TPX2 →	-0.945	-0.239	.002	.003	3	6
GBM	ZNF286B →	-0.635	-0.166	<.001	<.001	3	6
OV	MEX3A →	-1.246	-0.202	<.001	<.001	3	5
BRCA	ASPM →	-0.902	-0.255	.001	<.001	3	5
CCRCC	PRR11 →	-0.387	-0.134	<.001	.006	3	5
LSCC	TMEM156 →	+0.902	+0.162	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009072 vs TPX2 — BRCA

Explore this scatter interactively →