Aromatic amino acid metabolic process

Across TCGA cell cohorts, RNA activity of the Aromatic amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL12, ARHGEF17, and ATP5MC1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aromatic amino acid metabolic process activity versus RPL12 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RPL12 →	+1.293	+0.150	.001	.001	3	13
LARGE_INTESTINE	ARHGEF17 →	-1.474	-0.146	.004	.001	3	13
UPPER_AERODIGESTIVE_TRACT	ATP5MC1 →	+1.250	+0.160	<.001	.002	3	13
UPPER_AERODIGESTIVE_TRACT	HECTD4 →	-0.776	-0.137	.001	<.001	3	12
BLOOD_Leukemia	ANKLE2 →	-0.808	-0.124	<.001	<.001	3	12
BLOOD_Leukemia	CCDC186 →	-0.942	-0.140	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009072 vs RPL12 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →