Aromatic amino acid metabolic process

Across TCGA cell cohorts, RNA activity of the Aromatic amino acid metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FFAR3, PIP5K1A, and PEX2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FFAR3 grouped by Aromatic amino acid metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FFAR3 →	+0.183	+1.144	.006	.008	3	4
SOFT_TISSUE	PIP5K1A →	+0.473	+1.761	.002	<.001	3	3
LARGE_INTESTINE	PEX2 →	-0.306	-0.307	.001	.006	3	3
SKIN	LAPTM4A →	-0.146	-1.628	.006	.004	3	3
BONE	CXCR4 →	+0.960	+2.394	<.001	.004	3	3
BONE	AKR7A3 →	+0.255	+2.155	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FFAR3 by Aromatic amino acid metabolic process activity — LUNG_SCLC

Explore this box plot interactively →