Aromatic amino acid metabolic process

Across TCGA cell cohorts, RNA activity of the Aromatic amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM22, RNF144B, and HAUS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aromatic amino acid metabolic process activity versus TRIM22 in BLOOD_Lymphoma (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TRIM22 →	-2.723	-1.513	<.001	<.001	3	5
BLOOD_Lymphoma	RNF144B →	-3.365	-1.272	<.001	.001	3	5
BLOOD_Lymphoma	HAUS2 →	-0.866	-1.357	<.001	<.001	3	5
BLOOD_Lymphoma	RCSD1 →	-3.071	-1.075	<.001	<.001	3	5
PANCREAS	EEF1B2 →	+0.927	+1.404	<.001	<.001	3	5
PANCREAS	SLC5A6 →	+0.719	+1.230	.007	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009072 vs TRIM22 — BLOOD_Lymphoma

Explore this scatter interactively →