Across TCGA pan-cancer cohorts, RNA activity of the Serine family amino acid catabolic process pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 14 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Serine family amino acid catabolic process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and MESO, show the opposite pattern, with higher activity associated with better survival.

KIRP, COAD, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.697	0.390	.002	59	view →
COAD	OS	Median	All	0.726	0.868	.003	45	view →
KIRC	DFS	Quartile	All	0.540	0.823	.002	42	view →
MESO	DFS	Quartile	All	0.845	0.168	.006	39	view →
LIHC	OS	Tertile	All	0.832	0.675	.001	37	view →
STAD	DFS	Tertile	III,IV	0.693	0.466	.002	36	view →
SCLC	OS	Median	All	0.510	0.255	.003	33	view →
CHOL	OS	Tertile	II,III,IV	0.340	0.793	.025	24	view →
SKCM	OS	Median	II,III,IV	0.517	0.314	.003	18	view →
DLBC	DFS	Median	II,III,IV	0.457	0.896	.003	14	view →
GBM	OS	Quartile	All	0.224	0.548	.009	12	view →
ESCA	DFS	Tertile	IV	0.127	0.609	.038	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

Exploration

Same pathway, other analysis: tumor-vs-normal Serine family amino acid catabolic process activity · full GO:0009071 profile