Aspartate family amino acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Aspartate family amino acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAP1A, NAP1L2, and ZNF638, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aspartate family amino acid biosynthetic process activity versus RAP1A in COAD (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RAP1A →	+0.358	+0.158	.005	.001	3	4
BRCA	NAP1L2 →	+0.565	+0.104	<.001	<.001	3	4
COAD	ZNF638 →	+0.333	+0.149	.006	.003	3	4
OV	RPL7AP28 →	+0.687	+0.123	.008	.001	3	4
BRCA	C7 →	+1.168	+0.141	.009	.001	3	4
BRCA	ST3GAL5 →	+0.443	+0.119	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009067 vs RAP1A — COAD

Explore this scatter interactively →