Aspartate family amino acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Aspartate family amino acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRCP, PACS2, and EVI5L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRCP grouped by Aspartate family amino acid biosynthetic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CRCP →	-0.736	-1.140	<.001	.009	3	5
LUNG_SCLC	PACS2 →	-0.987	-1.085	<.001	.001	3	4
LARGE_INTESTINE	EVI5L →	-0.586	-0.791	.001	.001	3	4
LARGE_INTESTINE	NDUFS4 →	+0.713	+0.956	<.001	.002	3	4
SOFT_TISSUE	ERG28 →	+0.724	+1.275	.006	.006	3	3
SOFT_TISSUE	HNRNPUL2 →	+0.639	+1.554	.003	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRCP by Aspartate family amino acid biosynthetic process activity — LIVER

Explore this box plot interactively →