Aspartate family amino acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Aspartate family amino acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTLL12, SORD, and HIF1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aspartate family amino acid biosynthetic process activity versus TTLL12 in STOMACH (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TTLL12 →	+1.177	+0.430	<.001	<.001	3	6
BONE	SORD →	+2.602	+0.472	<.001	.002	3	6
KIDNEY	HIF1A →	-2.154	-0.272	.007	.001	3	6
SKIN	ACO2 →	+1.334	+0.432	<.001	<.001	3	6
SKIN	ARHGAP23 →	-2.053	-0.321	.007	.006	3	6
STOMACH	TKFC →	+0.878	+0.445	.005	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009067 vs TTLL12 — STOMACH

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