Amino acid catabolic process

Across TCGA patient cohorts, RNA activity of the Amino acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAD51AP1, TEX10, and NEMP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid catabolic process activity versus RAD51AP1 in GBM (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RAD51AP1 →	-0.640	-0.179	.002	<.001	3	7
LSCC	TEX10 →	-0.466	-0.243	.002	<.001	3	7
LSCC	NEMP1 →	-0.633	-0.232	<.001	<.001	3	7
LSCC	ASPM →	-0.900	-0.194	<.001	.001	3	7
COAD	LIN9 →	-0.573	-0.171	<.001	.002	3	7
PDAC	KLF15 →	+0.651	+0.121	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009063 vs RAD51AP1 — GBM

Explore this scatter interactively →