Amino acid catabolic process

Across TCGA cell cohorts, RNA activity of the Amino acid catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL38, ABCA12, and ZFP36L1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPL38 grouped by Amino acid catabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MRPL38 →	+0.335	+0.110	.007	.005	2	7
SKIN	ABCA12 →	+0.267	+0.069	<.001	<.001	3	5
LIVER	ZFP36L1 →	-0.556	-0.076	<.001	.001	3	5
BLOOD_Leukemia	SSR1 →	-0.172	-0.040	<.001	<.001	3	5
LIVER	TTC9 →	+0.255	+0.118	.002	.003	3	4
LIVER	SOX3 →	+0.251	+0.089	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPL38 by Amino acid catabolic process activity — LUNG_SCLC

Explore this box plot interactively →