Amino acid catabolic process

Across TCGA cell cohorts, RNA activity of the Amino acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERBB3, TRAPPC6A, and TJP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid catabolic process activity versus ERBB3 in LIVER (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ERBB3 →	+4.114	+0.213	.001	.009	3	6
URINARY_TRACT	TRAPPC6A →	+1.752	+0.304	.005	.002	3	6
PANCREAS	TJP3 →	+2.368	+0.292	.001	.001	3	6
URINARY_TRACT	FAAH →	+3.887	+0.420	<.001	.001	3	6
BREAST	MARVELD3 →	+3.039	+0.353	<.001	<.001	3	6
STOMACH	MPZL3 →	+2.121	+0.275	.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009063 vs ERBB3 — LIVER

Explore this scatter interactively →