Fatty acid catabolic process

Across TCGA cell cohorts, RNA activity of the Fatty acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RUVBL1, POLR1E, and MMEL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid catabolic process activity versus RUVBL1 in PANCREAS (Pearson r = -0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RUVBL1 →	-0.960	-0.262	<.001	<.001	3	7
PANCREAS	POLR1E →	-1.172	-0.302	<.001	<.001	3	6
PANCREAS	MMEL1 →	+2.254	+0.253	.005	.001	3	6
BONE	HNRNPA1 →	-0.728	-0.332	<.001	<.001	3	6
BREAST	SNRPA →	-0.611	-0.226	<.001	<.001	3	6
LARGE_INTESTINE	SLC44A3 →	+1.401	+0.143	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009062 vs RUVBL1 — PANCREAS

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