Aerobic respiration

Across TCGA patient cohorts, RNA activity of the Aerobic respiration pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS8_T130, SRCIN1_S165, and ATPAF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aerobic respiration activity versus RPS8_T130 in UCEC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS8_T130 →	-0.653	-0.104	<.001	.005	3	5
LSCC	SRCIN1_S165 →	+1.469	+0.042	<.001	<.001	3	5
LSCC	ATPAF1 →	+0.397	+0.029	<.001	.001	3	5
LSCC	TAOK3 →	-0.171	-0.024	.001	<.001	3	5
HNSC	ANXA2_S164 →	-0.502	-0.087	<.001	<.001	3	5
GBM	PFKFB2_S493 →	+0.666	+0.038	.003	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009060 vs RPS8_T130 — UCEC

Explore this scatter interactively →