Aerobic respiration

Across TCGA cell cohorts, RNA activity of the Aerobic respiration pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRODH, SLC16A6, and GBP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRODH grouped by Aerobic respiration-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRODH →	+3.326	+0.349	<.001	<.001	3	4
BREAST	SLC16A6 →	+1.408	+0.275	<.001	<.001	3	4
BREAST	GBP1 →	-1.553	-0.279	.003	<.001	3	4
BREAST	RAC2 →	-2.151	-0.351	<.001	<.001	3	4
BREAST	COX17 →	+0.590	+0.299	.001	<.001	3	4
SOFT_TISSUE	EFHD2 →	-1.738	-0.290	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRODH by Aerobic respiration activity — BREAST

Explore this box plot interactively →