Aerobic respiration

Across TCGA cell cohorts, RNA activity of the Aerobic respiration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AVPI1, SRRM1, and UHRF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aerobic respiration activity versus AVPI1 in LUNG_NSCLC_LUAD (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AVPI1 →	+1.655	+0.264	<.001	<.001	3	6
LUNG_NSCLC_LUAD	SRRM1 →	-0.577	-0.240	<.001	<.001	3	6
BLOOD_Leukemia	UHRF1 →	-1.872	-0.205	<.001	<.001	3	6
SOFT_TISSUE	INCENP →	-1.338	-0.326	.007	.004	3	5
PANCREAS	LMNB2 →	-1.028	-0.205	.005	.002	3	5
SOFT_TISSUE	TENT4A →	-1.160	-0.388	.009	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009060 vs AVPI1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →