Carbohydrate transport

Across TCGA cell cohorts, RNA activity of the Carbohydrate transport pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXE1, CBLC, and TPI1P2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FOXE1 grouped by Carbohydrate transport-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FOXE1 →	-0.506	-1.546	.008	.003	3	5
BLOOD_Myeloma	CBLC →	+0.207	+1.725	.001	<.001	3	5
PANCREAS	TPI1P2 →	+0.313	+1.185	.003	<.001	3	4
SOFT_TISSUE	TP53I3 →	-0.218	-1.240	.008	.001	3	4
SOFT_TISSUE	GSE1 →	+0.188	+1.289	.002	.008	3	4
SOFT_TISSUE	IGSF6 →	-0.180	-1.011	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FOXE1 by Carbohydrate transport activity — BLOOD_Myeloma

Explore this box plot interactively →