Apoptotic mitochondrial changes

Across TCGA patient cohorts, RNA activity of the Apoptotic mitochondrial changes pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC00894, OGDH, and FTO, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apoptotic mitochondrial changes activity versus LINC00894 in GBM (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LINC00894 →	+0.306	+0.129	.005	.006	3	5
CCRCC	OGDH →	+0.369	+0.140	.007	.003	3	4
CCRCC	FTO →	+0.377	+0.144	.004	.001	3	4
CCRCC	TARS2 →	+0.222	+0.098	.001	.005	3	4
CCRCC	EFNA1 →	+0.638	+0.116	.001	.001	3	4
HNSC	MCC →	+0.532	+0.095	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008637 vs LINC00894 — GBM

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