Apoptotic mitochondrial changes

Across TCGA cell cohorts, RNA activity of the Apoptotic mitochondrial changes pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAS6, COCH, and RAB3A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apoptotic mitochondrial changes activity versus GAS6 in BONE (Pearson r = -0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GAS6 →	-5.935	-0.330	<.001	.003	3	6
LIVER	COCH →	+4.176	+0.256	<.001	.006	3	5
LUNG_SCLC	RAB3A →	+1.751	+0.162	.001	.004	3	5
BREAST	NR3C1 →	-1.774	-0.291	<.001	<.001	3	5
BONE	FOSL1 →	-5.812	-0.320	<.001	.001	3	5
LUNG_NSCLC_LUAD	DKK1 →	-2.073	-0.148	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008637 vs GAS6 — BONE

Explore this scatter interactively →