Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

pathway activity — cross-omics
GO:0008635Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BOK_S8, RETREG2_S385, and BOK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADBOK_S8 →+0.984+0.271<.001<.00136
LSCCRETREG2_S385 →+0.828+0.093<.001<.00135
CCRCCBOK →+0.501+0.235<.001<.00135
LUADRAB11FIP2_S277 →+1.116+0.176<.001<.00135
LUADSNX14_S487 →+0.809+0.234<.001.00134
COADSRRM2_S908 →-0.697-0.167.002<.00125
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration