Intrinsic apoptotic signaling pathway in response to oxidative stress

Across TCGA patient cohorts, RNA activity of the Intrinsic apoptotic signaling pathway in response to oxidative stress pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYOF, RTL10, and DENND5B-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intrinsic apoptotic signaling pathway in response to oxidative stress activity versus MYOF in GBM (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MYOF →	+0.790	+0.190	<.001	<.001	3	4
CCRCC	RTL10 →	-0.225	-0.119	<.001	.008	3	4
CCRCC	DENND5B-AS1 →	-0.286	-0.144	<.001	.001	3	4
OV	IQSEC3 →	-0.761	-0.137	.003	.003	3	3
OV	CIB1 →	+0.510	+0.134	.009	.008	2	4
OV	SLC48A1 →	-0.458	-0.098	.007	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008631 vs MYOF — GBM

Explore this scatter interactively →