Intrinsic apoptotic signaling pathway in response to oxidative stress

Across TCGA cell cohorts, RNA activity of the Intrinsic apoptotic signaling pathway in response to oxidative stress pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PATL2, LRRC8E, and SERPINB12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PATL2 grouped by Intrinsic apoptotic signaling pathway in response to oxidative stress-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PATL2 →	-0.728	-0.953	.002	.003	3	4
SKIN	LRRC8E →	-1.283	-1.161	.001	.001	3	4
CNS	SERPINB12 →	+0.054	+0.918	.004	<.001	3	3
STOMACH	TROAP →	+1.226	+1.099	<.001	.007	3	3
SOFT_TISSUE	HOXA1 →	+1.033	+1.117	.006	.003	3	3
SOFT_TISSUE	ANKRD26 →	+0.412	+1.175	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PATL2 by Intrinsic apoptotic signaling pathway in response to oxidative stress activity — PANCREAS

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