Intrinsic apoptotic signaling pathway in response to DNA damage

Across TCGA patient cohorts, RNA activity of the Intrinsic apoptotic signaling pathway in response to DNA damage pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXorf21, GIMAP6, and PTPRC, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intrinsic apoptotic signaling pathway in response to DNA damage activity versus CXorf21 in DLBC (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	CXorf21 →	+1.489	+0.063	<.001	.001	3	33
SCLC	GIMAP6 →	+1.801	+0.093	<.001	<.001	3	33
CHOL	PTPRC →	+1.990	+0.047	<.001	<.001	3	33
CHOL	TNFAIP3 →	+1.720	+0.053	<.001	<.001	3	32
LAML	FGD2 →	+1.501	+0.024	<.001	<.001	3	32
UVM	ATM →	+1.438	+0.035	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008630 vs CXorf21 — DLBC

Explore this scatter interactively →