Intrinsic apoptotic signaling pathway in response to DNA damage

Across TCGA patient cohorts, RNA activity of the Intrinsic apoptotic signaling pathway in response to DNA damage pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCE, CAB39L, and GFRA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intrinsic apoptotic signaling pathway in response to DNA damage activity versus FANCE in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FANCE →	+0.545	+0.115	.005	.001	3	4
BRCA	CAB39L →	-0.825	-0.148	<.001	<.001	3	4
BRCA	GFRA2 →	-0.238	-0.130	.001	<.001	3	4
BRCA	MAMDC2 →	-0.917	-0.139	<.001	<.001	3	4
LSCC	COX18 →	-0.303	-0.285	.005	.001	3	3
LSCC	SLC25A20 →	-0.413	-0.204	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008630 vs FANCE — BRCA

Explore this scatter interactively →