Intrinsic apoptotic signaling pathway in response to DNA damage

Across TCGA cell cohorts, RNA activity of the Intrinsic apoptotic signaling pathway in response to DNA damage pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTFR1, HDDC2, and KMT5A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intrinsic apoptotic signaling pathway in response to DNA damage activity versus MTFR1 in PANCREAS (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MTFR1 →	-0.760	-0.194	<.001	.002	3	5
LARGE_INTESTINE	HDDC2 →	-1.290	-0.279	<.001	<.001	3	5
STOMACH	KMT5A →	-1.271	-0.355	<.001	.001	3	5
LARGE_INTESTINE	NSUN4 →	-1.000	-0.361	<.001	<.001	3	5
BREAST	SERPINE3 →	+0.216	+0.144	.009	.004	3	4
SOFT_TISSUE	XRCC1 →	-0.782	-0.305	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008630 vs MTFR1 — PANCREAS

Explore this scatter interactively →