Extrinsic apoptotic signaling pathway via death domain receptors

Across TCGA patient cohorts, RNA activity of the Extrinsic apoptotic signaling pathway via death domain receptors pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFAIP3, PIK3CG, and ITGA4, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extrinsic apoptotic signaling pathway via death domain receptors activity versus TNFAIP3 in CHOL (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	TNFAIP3 →	+1.931	+0.042	<.001	.002	3	34
ESCA	PIK3CG →	+1.335	+0.083	<.001	<.001	3	32
DLBC	ITGA4 →	+2.123	+0.060	<.001	<.001	3	32
UVM	SCAF11 →	+1.029	+0.015	<.001	<.001	3	32
DLBC	GVINP1 →	+1.385	+0.050	<.001	.003	2	33
CHOL	ZBED6 →	+1.783	+0.039	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008625 vs TNFAIP3 — CHOL

Explore this scatter interactively →