Extrinsic apoptotic signaling pathway via death domain receptors

Across TCGA patient cohorts, RNA activity of the Extrinsic apoptotic signaling pathway via death domain receptors pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYO1F, ARHGAP45, and PLEKHO2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extrinsic apoptotic signaling pathway via death domain receptors activity versus MYO1F in GBM (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MYO1F →	+0.506	+0.046	<.001	<.001	3	9
GBM	ARHGAP45 →	+0.450	+0.047	<.001	<.001	3	9
OV	PLEKHO2 →	+0.333	+0.034	.004	.004	3	9
BRCA	WAS →	+0.494	+0.033	<.001	<.001	3	8
LSCC	ADA2 →	+0.428	+0.028	<.001	.006	3	8
GBM	BTK →	+0.403	+0.051	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008625 vs MYO1F — GBM

Explore this scatter interactively →