Extrinsic apoptotic signaling pathway via death domain receptors

Across TCGA cell cohorts, RNA activity of the Extrinsic apoptotic signaling pathway via death domain receptors pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC6A8, ITGA3, and ACVR1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extrinsic apoptotic signaling pathway via death domain receptors activity versus SLC6A8 in URINARY_TRACT (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SLC6A8 →	+3.172	+0.392	<.001	.007	3	5
LUNG_SCLC	ITGA3 →	-2.263	-0.207	.002	.003	3	4
URINARY_TRACT	ACVR1B →	+0.675	+0.374	<.001	.002	3	4
BONE	GNRH1 →	-0.729	-0.150	.003	.004	3	4
CNS	PHB2 →	+0.630	+0.170	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	C12orf75 →	-1.540	-0.212	.007	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008625 vs SLC6A8 — URINARY_TRACT

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