Photoreceptor cell morphogenesis

Across TCGA cell cohorts, RNA activity of the Photoreceptor cell morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TES, PATL2, and EPHX4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TES grouped by Photoreceptor cell morphogenesis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TES →	+1.610	+1.048	.003	.002	3	5
SOFT_TISSUE	PATL2 →	+0.269	+1.628	.002	<.001	3	3
OESOPHAGUS	EPHX4 →	-2.376	-1.700	.007	<.001	3	3
OESOPHAGUS	GPR160 →	-2.360	-1.805	.007	<.001	3	3
LUNG_NSCLC_LUAD	SLCO2A1 →	+1.610	+0.982	.002	<.001	3	3
SKIN	VPS29 →	+0.573	+1.287	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TES by Photoreceptor cell morphogenesis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →