Regulation of Notch signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of Notch signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLXNA1, RPS7, and SSH3, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Notch signaling pathway activity versus PLXNA1 in URINARY_TRACT (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PLXNA1 →	+1.404	+0.077	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	RPS7 →	-1.016	-0.053	<.001	.001	3	12
BONE	SSH3 →	+1.929	+0.064	<.001	<.001	3	12
OESOPHAGUS	AGRN →	+2.606	+0.096	<.001	<.001	3	12
LIVER	JAG1 →	+2.269	+0.085	.004	<.001	3	12
URINARY_TRACT	EPHA1 →	+2.883	+0.091	.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008593 vs PLXNA1 — URINARY_TRACT

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