Regulation of Notch signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of Notch signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAC1, TBCD, and EIF2AK1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Notch signaling pathway activity versus RAC1 in BLOOD_Myeloma (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RAC1 →	+1.187	+0.272	.006	.001	3	4
BLOOD_Myeloma	TBCD →	+0.723	+0.334	.003	.003	3	4
BLOOD_Myeloma	EIF2AK1 →	+1.122	+0.251	.002	.001	3	4
BLOOD_Leukemia	ICAM2 →	+1.560	+0.707	<.001	<.001	3	4
LARGE_INTESTINE	RPL30 →	-0.569	-0.860	.007	.001	3	4
BLOOD_Myeloma	N4BP1 →	+1.024	+0.333	.004	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008593 vs RAC1 — BLOOD_Myeloma

Explore this scatter interactively →