Fibroblast growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Fibroblast growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMB2, TSHZ3, and MXRA8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fibroblast growth factor receptor signaling pathway activity versus LAMB2 in BRCA (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LAMB2 →	+0.517	+0.587	.009	.001	3	6
LSCC	TSHZ3 →	+0.689	+0.857	.001	.001	3	6
LSCC	MXRA8 →	+0.838	+0.777	<.001	.004	3	6
CCRCC	LHFPL6 →	+0.857	+0.877	<.001	<.001	3	6
CCRCC	DACT3 →	+0.601	+0.823	.001	<.001	3	6
LUAD	CARMN →	+0.442	+0.634	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008543 vs LAMB2 — BRCA

Explore this scatter interactively →