Fibroblast growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Fibroblast growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAP1, CRADD, and RPS27L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAP1 grouped by Fibroblast growth factor receptor signaling pathway-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CAP1 →	-0.899	-0.785	.001	.004	3	4
BREAST	CRADD →	-0.957	-0.867	<.001	.001	3	4
LUNG_NSCLC_LUAD	RPS27L →	-0.939	-0.777	.003	.002	3	4
LUNG_NSCLC_LUSC	ITPR2 →	-1.160	-1.130	.003	.008	3	3
LUNG_NSCLC_LUSC	INPP1 →	-1.929	-1.424	.001	.003	3	3
BLOOD_Myeloma	EPS8L1 →	+1.599	+1.284	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAP1 by Fibroblast growth factor receptor signaling pathway activity — PANCREAS

Explore this box plot interactively →