Fibroblast growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Fibroblast growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NLK, NSMCE2, and TCF7L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fibroblast growth factor receptor signaling pathway activity versus NLK in BONE (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NLK →	-1.103	-0.456	.003	.002	3	4
BLOOD_Lymphoma	NSMCE2 →	-1.046	-0.247	.003	.001	3	4
UPPER_AERODIGESTIVE_TRACT	TCF7L1 →	-0.964	-0.242	.009	.003	2	5
BONE	PFDN1 →	-0.855	-0.351	.006	<.001	3	3
BONE	POLDIP2 →	-1.009	-0.393	.003	.009	3	3
SOFT_TISSUE	SPICE1 →	+0.895	+0.360	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008543 vs NLK — BONE

Explore this scatter interactively →