Respiratory chain complex IV assembly

Across TCGA patient cohorts, RNA activity of the Respiratory chain complex IV assembly pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMOC2, RECK, and PDE1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory chain complex IV assembly activity versus SMOC2 in OV (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SMOC2 →	-0.793	-0.137	.007	.006	3	4
OV	RECK →	-0.688	-0.145	<.001	.004	3	4
OV	PDE1B →	-0.534	-0.142	.006	.004	3	4
OV	FBN1 →	-1.241	-0.151	.002	.004	3	4
UCEC	CNRIP1 →	-0.800	-0.166	<.001	.006	3	4
UCEC	PTGIS →	-1.471	-0.246	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008535 vs SMOC2 — OV

Explore this scatter interactively →