Respiratory chain complex IV assembly

Across TCGA cell cohorts, RNA activity of the Respiratory chain complex IV assembly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRAT2, MICAL2, and CCNE2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory chain complex IV assembly activity versus FRAT2 in LARGE_INTESTINE (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FRAT2 →	+0.908	+0.845	.002	.005	3	5
LUNG_NSCLC_LUAD	MICAL2 →	-2.308	-1.074	<.001	<.001	3	5
LUNG_SCLC	CCNE2 →	-1.088	-0.799	.006	.002	3	5
OVARY	TMED7 →	-0.703	-0.943	.001	.003	3	4
LARGE_INTESTINE	PTPN1 →	-0.913	-0.777	.002	.004	3	4
BLOOD_Lymphoma	MRPL45 →	+0.665	+0.322	.002	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008535 vs FRAT2 — LARGE_INTESTINE

Explore this scatter interactively →