Regulation of cell size

Across TCGA patient cohorts, RNA activity of the Regulation of cell size pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL3A1, MFAP2, and STAB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell size activity versus COL3A1 in LUAD (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	COL3A1 →	+0.664	+0.026	<.001	.001	3	7
OV	MFAP2 →	+0.808	+0.032	.005	.002	3	7
LUAD	STAB1 →	+0.369	+0.025	<.001	.002	3	7
CCRCC	C1QC →	+0.432	+0.017	.006	.007	3	7
CCRCC	EMILIN1 →	+0.580	+0.025	.001	.003	3	7
BRCA	RCN3 →	+0.533	+0.023	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008361 vs COL3A1 — LUAD

Explore this scatter interactively →