Regulation of cell size

Across TCGA cell cohorts, RNA activity of the Regulation of cell size pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PANX1, NLGN4X, and PRMT3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell size activity versus PANX1 in KIDNEY (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PANX1 →	+0.982	+0.168	.003	.009	2	5
PANCREAS	NLGN4X →	-0.033	-0.192	.002	.004	3	4
OESOPHAGUS	PRMT3 →	-1.098	-0.258	.004	.001	3	4
LUNG_NSCLC_LUAD	PHLDA2 →	+1.620	+0.232	.005	.001	3	4
LUNG_NSCLC_LUAD	CEBPA →	-1.289	-0.228	.002	<.001	3	4
URINARY_TRACT	ZNF639 →	+0.987	+0.454	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008361 vs PANX1 — KIDNEY

Explore this scatter interactively →