Regulation of cell shape

Across TCGA patient cohorts, RNA activity of the Regulation of cell shape pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYGL, VWA8, and C19orf44, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell shape activity versus PYGL in COAD (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PYGL →	-1.258	-1.197	.002	.001	3	1
COAD	VWA8 →	-0.500	-1.095	.004	.004	3	1
COAD	C19orf44 →	-0.607	-1.320	.001	.005	3	1
COAD	DARS2 →	-0.735	-1.184	.001	.002	3	1
COAD	ECRG4 →	+0.645	+1.243	.005	<.001	3	1
COAD	SNRPN →	+0.500	+1.238	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008360 vs PYGL — COAD

Explore this scatter interactively →