Regulation of cell shape

Across TCGA cell cohorts, RNA activity of the Regulation of cell shape pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D2, ETV1, and ANXA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell shape activity versus TBC1D2 in BLOOD_Leukemia (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TBC1D2 →	+0.653	+0.134	<.001	.002	3	5
STOMACH	ETV1 →	-3.145	-0.248	<.001	<.001	3	5
PANCREAS	ANXA3 →	+3.385	+0.302	.002	<.001	3	5
LARGE_INTESTINE	ADAM9 →	+0.828	+0.246	.007	<.001	3	5
LUNG_NSCLC_LUAD	MYO1C →	+1.149	+0.201	<.001	<.001	3	5
PANCREAS	SLPI →	+3.501	+0.298	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008360 vs TBC1D2 — BLOOD_Leukemia

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