Glial cell migration

Across TCGA patient cohorts, RNA activity of the Glial cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAP, FHL3, and FSTL1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell migration activity versus FAP in LSCC (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FAP →	+0.776	+0.046	<.001	<.001	3	9
UCEC	FHL3 →	+0.592	+0.084	<.001	<.001	3	9
BRCA	FSTL1 →	+0.539	+0.031	<.001	<.001	3	9
LSCC	SRRM2_S2123 →	-0.372	-0.052	<.001	<.001	3	8
LSCC	TIMP2 →	+0.694	+0.051	<.001	<.001	3	8
CCRCC	VCAN →	+0.991	+0.059	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008347 vs FAP — LSCC

Explore this scatter interactively →