Glial cell migration

Across TCGA patient cohorts, RNA activity of the Glial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGSF8, SLC25A19, and WDFY4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell migration activity versus IGSF8 in OV (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IGSF8 →	+0.603	+0.173	.008	.008	3	5
CCRCC	SLC25A19 →	-0.298	-0.198	.002	.005	3	4
CCRCC	WDFY4 →	-0.665	-0.308	.001	.008	3	4
CCRCC	CD6 →	-0.718	-0.313	.001	.007	3	4
CCRCC	CASTOR1 →	+0.278	+0.347	.002	.009	3	4
CCRCC	HLA-DOB →	-0.542	-0.192	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008347 vs IGSF8 — OV

Explore this scatter interactively →